Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis
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چکیده
منابع مشابه
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
Transient exposure of beta-cells to oxidative stress interrupts the transduction of signals normally coupling glucose metabolism to insulin secretion. We investigated putative persistence of effects induced by one transient oxidative stress (200 microm H(2)O(2), 10 min) on insulin secreting cells following recovery periods of days and weeks. Three days after oxidative stress INS-1E cells and ra...
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BACKGROUND Epidemiological evidence suggests that exposure to ambient air fine particulate matter (PM2.5) increases the risk of developing type 2 diabetes and cardiovascular disease. However, the mechanisms underlying these effects of PM2.5 remain unclear. OBJECTIVES We tested the hypothesis that PM2.5 exposure decreases vascular insulin sensitivity by inducing pulmonary oxidative stress. M...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2018
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-018-2197-9